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Armen Y
 
Armen Mulkidjanian

 

 

Postal address: University of Osnabrück, Department of Physics, Barbarastr. 7,49076, Osnabrück, Germany

Phone:     +49-541-9692698; Fax: +49-541-9692656; E-mail: amulkid@uos.de.

Web page: http://www.macromol.uni-osnabrueck.de/Projects_Mulkidjanian.php.

 

Research Interests

molecular mechanisms and evolution of biological energy conversion,

enzymology and biophysics of membrane proteins,

comparative genomics of membrane proteins.

 

Degrees and Grades

2006 – Doctor of Sciences (Biology), Lomonosov Moscow State University, Moscow, Russia.

2002 – Dr. rer. nat. habil. (Biophysics), University of Osnabrück, Germany.

1984 – Ph.D. (Biophysics), Lomonosov Moscow State University, Moscow, Russia.

1980 – MSc. (Biophysics, with honours), Lomonosov Moscow State University, Moscow, Russia.

 

Current Affiliations

2012                   Professor (part-time), School of Bioengineering and Bioinformatics,
Lomonosov Moscow State University, Moscow, Russia,

2006 –                   Research Faculty, Department of Physics, University of Osnabrück, Germany,

2002 –                   Privat-Dozent, Department of Biology/Chemistry, University of Osnabrück, Germany,

 

Previous Positions

2006 – 2012           Adjunct Professor, School of Bioengineering and Bioinformatics,
Lomonosov Moscow State University, Moscow, Russia,

2001 – 2004           Research Scientist and Principle Investigator at the Division of Biophysics, Dapartment of Biology and Chemistry, University of Osnabrück, Germany.

1999 - 2001           Research Scientist at the Division of Biophysics, Department of Biology and Chemistry, University of Osnabrück, Germany.

1996 – 1999           Habilitation Fellow at the Division of Biophysics, Department of Biology and Chemistry, University of Osnabrück, Germany.

1993 – 1995           Humboldt Research Fellow at the Division of Biophysics, Department of Biology and Chemistry, University of Osnabrück, Germany.

1991 –                   Senior Investigator (on leave from 1993), A.N.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.

1989 – 1991           Investigator, A.N.Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.

1987 – 1989           Investigator, Department of Biophysics, School of Biology, Lomonosov Moscow State University, Moscow, Russia.

1984 – 1986           Junior Investigator, Department of Biophysics, School of Biology, Lomonosov Moscow State University, Moscow, Russia.

 

Visiting positions

2005 – 2006                  Mercator-C3-Professorship of the Deutsche Forschungsgemeinschaft at the Department of Physics, University of Osnabrück, Germany.

1999 –                          Visiting Scientist at the National Center for Biotechnology Information, National Institutes of Health, Bethesda, USA (almost each year).

1991 – 1992                  EMBO Visiting Fellow at the University of Bologna, Italy.

 


Current Research Grants

2007 – 2013           Research Grant of the Deutsche Forschungsgemeinschaft on Subnanoscopic charge displacements in the ubiquinone-reducing center of the Rhodobacter capsulatus cytochrome bc1 complex (€ 200000).

2008 – 2013           Collaborative Research Grant of the Deutsche Forschungsgemeinschaft on Nano-electrostatics of biological interfaces (€ 200000 The project involves two German and three Russian research groups).

2009 – 2013           EU-COST Action CM0902: Molecular machineries for ion translocation across biomembranes (17 European countries are involved, about € 5000 for exchange visits per year)

2010 – 2013           Grant from the “Mitotech” corporation (Russia) Investigation of the peroxidation of cardiolipin in model systems (€ 35000).

 

Previous Research Grants

2010 – 2011      Russian government research grant for Russian scientists living abroad (2010-1.5-000-011-025) Investigation of the interaction between cardiolipin and the cytochrome bc1 complex of mammalian mitochondria (€ 65000).

2002 – 2005      EU Grant on Nano-scale electromechanics of the FoF1 ATP synthase and the cytochrome bc1 complex – EU-INTAS Call 2001 on Nano-scale Materials and Structures (€ 60000);

2002 – 2005      VW-Foundation research grant Study of relaxation modes that control the intra-protein electron transfer at nanoseconds and microseconds: Photosynthetic reaction center of Rps. viridis (together with C.R.D. Lancaster, Map-Planck-Institute of Biophysics, € 190000)

2001 – 2004      Dynamik und Kopplung der Membranproteine in Rhodobacter capsulatus (2002-2004, DFG-SFB 431-TP15, together with W. Junge, € 340000);

1996 – 1999      Habilitation Fellowship and Research Grant from the Deutsche Forschungsgemeischaft at the University of Osnabrück, Germany.

1993 – 1995      Humboldt Research Fellowship and Travel Grant at the University of Osnabrück, Germany.

 

professional services

2012                     Organizer of the Special COST Session “Proton Translocation across the Membranes” and Co-organizer of the Special Session “Phylogenomics of the Energy-Transducing Enzymes” (together with Prof. C. Hagerhall) (16th European Bioenergetic Conference, Freiburg, Germany)

2010                     Organisation of the first meeting of the EU-COST Action CM0902: Molecular machineries for ion translocation across biomembranes (Hofheit an Taurus, Germany).

2009 –                   National representative of Germany in the EU-COST Action CM0902: Molecular machineries for ion translocation across biomembranes

2009 –                   Member of the German Biophysical Society

2008                     Co-organizer of the Symposium on Genomics and Evolution of the Energy-Transducing Systems (15th European Bioenergetic Conference, Dublin, Ireland).

2006 –                   Member of the Scientific Council, Research Center of Mitoengineering, Lomonosov Moscow State University, Moscow, Russia

2006                     Co-organizer of the 14th European Bioenergetic Conference, Moscow, Russia.    

2004                   Invited Foreign Member, The Biophysical Society (USA).

2002 - 2006           Scientific Coordinator of an EC-INTAS cooperation project on Nano-scale electromechanics of the FoF1 ATP synthase and the cytochrome bc1 complex. The project involves two Russian, one German and one Italian research group.

2001                     Evaluation Expert of the European Commission, Program: Quality of Life, Subject Field: Biotechnology.

1996                     Co-organizer of a Workshop of the European Science Foundation on the Structure and Function of the Cytochrome bf Complexes, Regensburg, Germany.

1994-1999             Scientific Coordinator of an EC-INTAS cooperation project on electrostatics of energy-transducing proteins. The project involved two Russian, one German and one French research group.

2011 –                   Reviewer for the state funding agencies of France ans Switzerland

1989 –                   Reviewer for diverse journals including Nature, Cell, PNAS, NAR, Molecular Biology and Evolution,  EMBO Journal, J. Am. Chem. Soc., Biochemistry, FEBS Letters, Biochimica et Biophysica Acta, Applied Surface Science, Origin of Life and Evolution of Biosphere.


 

Major conference talks

2013     Invited Plenary Speaker, the 48th Winter Seminar “Biophysical Chemistry, Molecular Biology and Cybernetics of Cell Functions (Manfred Eigen’s Winter Seminar), Klosters, Switzerland

2012     Invited Speaker, Symposium “Origin of life on the molecular level“, Lund University

2012     Plenary Speaker during the Moscow Science Festival, the major event of the All-Russian National Science Festival

2012     Organizer of two sessions, Speaker, 17th European Bioenergetic Conference, Freiburg, Germany

2012     Invited Speaker, Conference on Open Questions on the Origin of Life, Leicester

2012     Invited Speaker, Meeting of the Astrobiology Society, Atlanta, GA

2011     Speaker, ISSOL – The International Astrobiology Society and Bioastronomy Joint International Conference, Montpellier

2011     Invited Speaker, an Elizabeth and Frederick White Conference of the Australian Academy of Science “The Evolution of Photosynthesis and Oxygenation of the Earth”, Sydney.

2011     Speaker, 7th European Workshop on Bacterial Respiratory Chains, Höör, Sweden 

2011     Speaker, Joint Meeting of Swedish and German Biophysical Societies “Dynamics, Function, and Design of Biological Macromolecules”

2010     Invited Speaker, Symposium “Origin of Life”, Vienna Biozentrum;

2010     Session Chairman, Workshop on “Quinone and Oxygen in Energy Coupling and Catalysis, Satellite Meeting to the 16th European Bioenergetic Conference, Krakow;

2010     Keynote Speaker, Workshop on the Evolution of Photosynthesis, Russian Academy of Sciences, Moscow;

2010     Keynote Speaker, Gordon Research Conference on the Origin of Life, Galveston, TX;

2009     Plenary Speaker, 13th International Symposium on Phototrophic Prokaryotes, Montreal;

2009     Invited Speaker, Manfred-Eigen-Nachwuchswissenschaftlergespräche 2009 "Chemical Evolution", Delmenhorst

2009     Session Chairman, Gordon Research Conference on Protons and Membrane Reactions, Ventura, CA;

2008     Session Chairman, Invited Speaker, 15th European Bioenergetic Conference, Dublin.

2007     Invited Speaker, 14th International Photosynthesis Congress, Glasgow;

2006     Invited Speaker, 14th European Bioenergetic Conference, Moscow;

2006     Invited Speaker, Gordon Research Conference on Protons and Membrane Reactions, Ventura, CA;

2004     Plenary Speaker, 13th European Bioenergetics Conference, Pisa;

2001     Discussion Leader, Gordon Research Conference on Bioenergetics, New Hampshire;

2000     Discussion Leader, Gordon Research Conference on Photosynthesis, New Hampshire.

 

Teaching Experience (teachung languages: English, German and Russian)

2010 – current       Teaching Biophysical Methods (Summer Semester, together with Prof. H.-J. Steinhoff and Dr. J. Klare) at the Department of Physics, University of Osnabrück, Germany

2008 – current       Teaching Applied Bioinformatics (Winter Semester) at the Department of Physics, University of Osnabrück, Germany

2007 – 2011           Teaching Physical Chemistry of Biomacromolecules (Winter Semester, together with Dr. J. Klare) at the Department of Physics, University of Osnabrück, Germany

2006 - current       Block of lectures on Molecular Bioenergetics, School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.

2005 - current       Teaching Structure and Function of Biological Macromolecules (Winter Semester), and Molecular Enzymology (Summer Semester) at the Department of Physics, University of Osnabrück, Germany;

2002 – current       Supervision of PhD students at the University of Osnabrück, Germany (S. Klishin, M. Kozlova, K. Jahns, D. Dibrova, A. Lokhmatikov).

1996 –2004            Teaching Bioenergetics, participation in the practical course on Cell Biology and in the student seminar in Biophysics at the Department of Biology and Chemistry, University of Osnabrück, Germany;

1995 - current       Supervision of visiting Russian PhD students (O. Gopta, B. Feniouk, D. Knorre, F. Orekhov, M. Bozdaganyan, A. Makarov, O. Kropkacheva) during their work at the University of Osnabrück, Germany.

1990 – 1992           Co-organization and chairmanship of the College on Physico-Chemical Biology at the Lomonosov Moscow State University, Moscow, Russia;

1981 – current       Supervision of undergraduate students first at the Lomonosov Moscow State University, Moscow, Russia and then at the University of Osnabrück, Germany.

 

PUBLICATIONS

Dibrova, D.V., D. A. Cherepanov, M.Y. Galperin, V. P. Skulachev, A.Y. Mulkidjanian, 2013.
Evolution of cytochrome bc complexes: from membrane electron translocases to triggers of apoptosis, Biochim Biophys Acta
, accepted.

Koonin, E.V. and Mulkidjanian A.Y., 2013, Evolution of cell division: from shear mechanics to elaborate molecular choreography? Cell, in press

Mulkidjanian A.Y. and M.Y. Galperin, 2013. A Time to Scatter Genes and a Time to Gather Them: Evolution of Photosynthesis Genes in Bacteria, in: Genome Evolution of Photosynthetic Bacteria (Ed. T.S. Beatty) Advances in Botanical Research, vol. 66, in press, link to uncorrected proofs

Busch K.B., G. Deckers-Hebestreit, G.T. Hanke, and A.Y. Mulkidjanian, 2013, Dynamics of bioenergetic microcompartments. Biol Chem, 394: 163–188.

Mulkidjanian A.Y., A.Y. Bychkov, D.V, Dibrova, M.Y. Galperin, and E.V. Koonin, 2012 Open questions on the origin of life at anoxic geothermal fields. Orig Life Evol Biosph, 42:507-516.

D.V. Dibrova, M. Y. Chudetsky, M. Y. Galperin, E.V. Koonin, A.Y. Mulkidjanian: 2012. The role of energy in the emergence of biology from chemistry. Orig Life Evol Biosph, 42:459-468.

Dibrova D.V., K.S. Makarova, M.Y. Galperin, E.V. Koonin, A.Y. Mulkidjanian, 2012, Comparative analysis of lipid biosynthesis in archaea, bacteria and eukaryotes: What was the structure of the first membrane lipids? Biochim Biophys Acta  1817, S154

Winkelmann I., D.A.Cherepanov, K. Jahns, N. Voskoboynikova, A.Y. Mulkidjanian, 2012  Inhibitor titration of the cytochrome bc1 complex of Rhodobacter capsulatus by myxothiazol and pyraclostrobin: Evidence for a binding change mechanism, Biochim Biophys Acta  1817, S95

Orekhov P.S., K.V. Shaitan, A.Y. Mulkidjanian,  2012  Inter- and intra-monomeric communication in the cytochrome bc1 complex as studied by molecular dynamics simulations, Biochim Biophys Acta  1817, S95-S92

Lokhmatikov A.V., N. Voskoboynikova, D.A. Cherepanov, H.J.Steinhoff, V.P. Skulachev and A.Y. Mulkidjanian, 2012, Oxidation of cardiolipin in liposomes: A new insight into the primary steps of mitochondria-triggered apoptosis, Biochim Biophys Acta  1817, S100

Dibrova D.V., M.Y. Galperin, A.Y. Mulkidjanian. 2012 The cytochrome bc1 complex and the evolution of membrane bioenergetics, Biochim Biophys Acta  1817, S91

Mulkidjanian, A. Y., A. Y. Bychkov, D. V. Dibrova, M. Y. Galperin, and E. V. Koonin. 2012. Origin of first cells at terrestrial, anoxic geothermal fields. Proc Natl Acad Sci USA 109: E821-E820.

Mulkidjanian AY, Lankenau D-H: LUCA - letzter gemeinsamer Vorfahre allen Lebens. In: Moleküle aus dem All? Edited by Al-Shamery K. Weinheim: Wiley-VCH-Verlag; 2011: 137-188.

Mulkidjanian AY, Cleaves HJ: Substrate. In: Encyclopedia of Astrobiology. Edited by Amils R, Quintanilla C, Cleaves HJ, Irvine WM, Pinit DL, M. V. Heidelberg: Springer; 2011: 1614.

Mulkidjanian AY: Energetics of the first life. In: Origins of Life: The Primal Self-Organisation. Edited by Egel H, Lankenau D-H, Mulkidjanian AY. Heidelberg: Springer; 2011: 1-33.

Mulkidjanian AY: Abiotic Photosynthesis. In: Encyclopedia of Astrobiology. Edited by Amils R, Quintanilla C, Cleaves HJ, Irvine WM, Pinit DL, M. V. Heidelberg: Springer; 2011: 1-3.

Mulkidjanian, A.Y., M.Y. Galperin. 2010. On the abundance of zinc in the evolutionarily old protein domains (Letter). Proc. Natl. Acad. Sci. U.S.A,107, E137.

Mulkidjanian, A.Y. 2010. Activated Q-cycle as a common mechanism for cytochrome bc1 and cytochrome b6f complexes. Biochim. Biophys. Acta, 1797:1858-1868.

Dibrova, D.V., M.Y.Galperin, A.Y. Mulkidjanian, 2010. Characterization of the N-ATPase, a distinct, laterally transferred Na+-translocating form of the bacterial F-type membrane ATPase (Discovery Note). Bioinformatics, 26:1473-1476.

Neumann S, Fuchs A, Mulkidjanian A.Y., Frishman D. 2010. Current status of membrane protein structure classification. Proteins 78,1760-1773.

Mulkidjanian AY, Galperin MY: Evolutionary origins of membrane proteins; 2010.

Mulkidjanian, A.Y., M.Y. Galperin. 2010. On the abundance of zinc in the evolutionarily old protein domains (Letter). Proc. Natl. Acad. Sci. U.S.A, in press.

Mulkidjanian, A.Y. 2010. Activated Q-cycle as a common mechanism for cytochrome bc1 and cytochrome b6f complexes. Biochim. Biophys. Acta, in press, doi:10.1016/j.bbabio.2010.07.008.

Dibrova, D.V., M.Y.Galperin, A.Y. Mulkidjanian, 2010. Characterization of the N-ATPase, a distinct, laterally transferred Na+-translocating form of the bacterial F-type membrane ATPase (Discovery Note). Bioinformatics26:1473-1476.

Neumann S, Fuchs A, Mulkidjanian A.Y., Frishman D. 2010. Current status of membrane protein structure classification. Proteins 78,1760-1773.

Mulkidjanian, A.Y. 2009. On the origin of life in the Zinc World: 1. Photosynthetic, porous edifices built of hydrothermally precipitated zinc sulfide (ZnS) as cradles of life on Earth. Biol. Direct 4:26.

Mulkidjanian, A.Y., M.Y. Galperin. 2009. On the origin of life in the Zinc World. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth Biol. Direct 4:27.

Mulkidjanian, A.Y., M.Y. Galperin, E.V. Koonin. 2009. Co-evolution of membranes and membrane proteins, Trends Biochem. Sci. 34, 206-215.

Kozlova, M.A., H.D. Juhnke, D.A. CherepanovC.R.D Lancaster, A.Y. Mulkidjanian. 2008. Proton transfer in the photosynthetic reaction center of Blastochloris viridis, FEBS Letters, 582, 238-242.

Mulkidjanian, A.Y., P. Dibrov, M.Y. Galperin. 2008. The past and present of the sodium energetics: May the sodium-motive force be with you, Biochim. Biophys. Acta, 582, 238-242.

Mulkidjanian, A.Y., M.Y. Galperin, K.S. Makarova, Y.I. Wolf, E.V. Koonin, 2008. Evolutionary primacy of sodium bioenergetics, Biol Direct 3, 13.

Mulkidjanian, A.Y., K.S. Makarova, M.Y. Galperin and E.V. Koonin. 2007. Inventing the dynamo machine: On the origin of the F-type and V-type membrane ATPases from membrane RNA/protein translocasesNature Reviews Microbiology, 5:892-899.

Feniouk, B.A, A. Rebecci, D.Giovanni, S. Anefors, A.Mulkidjanian, W.Junge, P.Turina, and B.A.Melandri. 2007. Met23Lys mutation in subunit gamma of FOF1-ATP synthase from Rhodobacter capsulatus impairs the activation of ATP hydrolysis by protonmotive force. Biochim. Biophys. Acta1767:1319-1330.

Mulkidjanian, A.Y. and M. Y. Galperin. 2007. Physico-chemical and evolutionary constraints for the formation and selection of first biopolymers: Towards the consensus paradigm of the abiogenic origin of life. Chemistry and Biodiversity, 4:2003-2015.

Mulkidjanian. A.Y. 2007. Proton translocation by the cytochrome bc1 complexes of phototrophic bacteria: Introducing the activated Q-cycle. Photochem. Photobiol. Sci., 6:19-34.

Mulkidjanian, A.Y., J. Heberle, D.A. Cherepanov. 2006. Protons @ interfaces: Implications for biological energy conversion, Biochim. Biophys. Acta, 1757: 913-930.

Mulkidjanian, A.Y., E. V. Koonin, K. S. Makarova, S. L. Mekhedov, A. Sorokin, Y. I. Wolf, A. Dufresne, F. Partensky, H. Burd, D. Kaznadzey, R. Haselkorn, M. Y. Galperin 2006. The cyanobacterial genome core and the origin of photosynthesis, Proc. Natl. Acad. Sci. U.S.A., 103: 13126-13131.

Mulkidjanian, A.Y. 2006. Proton in the well and through the desolvation barrier, Biochim. Biophys. Acta, 1757: 415-427.

Mulkidjanian, A.Y., D.A. Cherepanov. 2006. Probing biological interfaces by tracing proton passage across them, Photochem. Photobiol. Sci. 5, 577-587.

Mulkidjanian, A.Y. 2005. Ubiquinol oxidation in the cytochrome bc complex: Reaction mechanism and prevention of short-circuitingBiochim. Biophys. Acta 1709:5-34.

Mulkidjanian,A.Y., D.A.Cherepanov, and M.A.Kozlova. 2005. Ubiquinone reduction in the photosynthetic reaction center of Rhodobacter sphaeroidesInterplay between electron transfer, proton binding and the flips of quinone ring. Biochem. Soc. Trans. 33:845-850.

Mulkidjanian,A.Y., D.A.Cherepanov, J.Heberle, and W.Junge. 2005. Proton transfer dynamics at membrane/water interface and the mechanism of biological energy conversion, Biochemistry-Moscow 70:251-256.

Feniouk,B.A., A.Y.Mulkidjanian, and W.Junge. 2005. Proton slip in the ATP synthase of Rhodobacter capsulatus: induction, proton conduction, and nucleotide dependence. Biochim. Biophys. Acta 1706:184-194.

Feniouk, B.A., M.A. Kozlova, D.A. Knorre, D.A. Cherepanov, A.Y. Mulkidjanian, and W. Junge. 2004. The proton driven rotor of ATP synthase: Ohmic conductance (10 fS), and absence of voltage gating. Biophys. J. 86: 4094-4109.

Cherepanov, D.A., W. Junge, and A.Y. Mulkidjanian. 2004. Proton transfer dynamics at the membrane/water interface: Dependence on the fixed and mobile pH buffers, the geometry of membrane particles, and the interfacial potential barrier. Biophys. J. 86:665-680.

Cherepanov, D.A., B.A. Feniouk, W. Junge, and A.Y. Mulkidjanian. 2003. Low dielectric permittivity of water at the membrane interface: effect on the energy coupling mechanism in biological membranes. Biophys. J. 85:1307-1316.

Mulkidjanian, A.Y., D.A. Cherepanov, and M.Y. Galperin. 2003. Survival of the fittest before the beginning of life: selection of the first oligonucleotide-like polymers by UV light. BMC. Evol. Biol 3:12.

Nikolskaya, A.N., A.Y. Mulkidjanian, I.B. Beech, and M.Y. Galperin. 2003. MASE1 and MASE2: two novel integral membrane sensory domains. J. Mol. Microbiol Biotechnol. 5:11-16.

Feniouk, B.A., D.A. Cherepanov, N.E. Voskoboynikova, A.Y. Mulkidjanian, and W. Junge. 2002. Chromatophore vesicles of Rhodobacter capsulatus contain on average one FOF1-ATP synthase each. Biophys. J. 82:1115-1122.

Junge, W., M. Haumann, R. Ahlbrink, A. Mulkidjanian, and J. Clausen. 2002. Electrostatics and proton transfer in photosynthetic water oxidation. Philos. Trans. R. Soc. Lond B Biol Sci. 357:1407-1417.

Klishin, S.S., W. Junge, and A.Y. Mulkidjanian. 2002. Flash-induced turnover of the cytochrome bc1 complex in chromatophores of Rhodobacter capsulatus: binding of Zn2+ decelerates likewise the oxidation of cytochrome b, the reduction of cytochrome c1 and the voltage generation. Biochim. Biophys. Acta 1553:177-182.

Galperin, MY, Gaidenko, TA, Mulkidjanian, AY, Nakano, M, Price, CW. 2001. MHYT, a new integral membrane sensor domain. FEMS Microbiol Lett, 205, 17-23.

Feniouk, BA, Cherepanov, DA, Junge, W, Mulkidjanian, AY. 2001. Coupling of proton flow to ATP synthesis in Rhodobacter capsulatus: FoF1-ATP synthase is absent from about half of chromatophoresBiochim. Biophys. Acta 1506, 189-203

Ahlbrink, R., Semin, B.K., Mulkidjanian, A.Y & Junge, W. 2001. Photosystem II of peas: Effects of added divalent cations of Mn, Fe, Mg, and Ca on two kinetic components of P680+-reduction in Mn-depleted core particles, Biochim. Biophys. Acta, 1506, 117-26.

Cherepanov, D.A., and Mulkidjanian, A.Y. 2001. Proton transfer in Azotobacter vinelandii ferredoxin I: Entatic Lys84 operates as elastic counterbalance for the proton-carrying Asp15, Biochim. Biophys. Acta, 1505, 179-184.

Cherepanov, D.A., Krishtalik. L.I., Mulkidjanian, A.Y., 2001. Photosynthetic electron transfer controlled by protein relaxation: Analysis by Langevin stochastic approach, Biophysical Journal, 80, 1033-1049.

Cherepanov, D.A., S.I. Bibikov, M.V. Bibikova, D.A. Bloch, L.A. Drachev, O.A. Gopta, D. Oesterhelt, A.Y. Semenov, and A.Y. Mulkidjanian. 2000. Reduction and protonation of the bound QB ubiquinone in the photosynthetic reaction centers of Rb. sphaeroides: Kinetic model based on a comparison between wild type chromatophores and the mutants with arginine substituted by isoleucine at 207 and 217 sites in the L-subunit. Biochim.Biophys.Acta1459, 10-34.

Mulkidjanian, A.Y. 1999b. Conformationally controlled pK-switching in membrane proteins: One more mechanism specific to the enzymatic catalysis? FEBS Lett., 463, 199-204.

Gopta, O.A., D.A. Cherepanov, W. Junge, and A.Y. Mulkidjanian. 1999. Proton transfer from the bulk to the bound ubiquinone QB of the reaction center in chromatophores of Rhodobacter sphaeroides: Retarded conveyance by neutral water. Proc.Natl.Acad.Sci.U.S.A. 96:13159-13164.

Cherepanov, D.A., A.Y. Mulkidjanian, and W. Junge. 1999. Transient accumulation of elastic energy in proton translocating ATP synthaseFEBS Lett. 449:1-6.

Feniouk, B.A., Cherepanov, D.A., Junge, W., Mulkidjanian, A.Y. 1999. ATP-synthase of Rhodobacter capsulatus: coupling of proton flow through FO to reactions in F1 under ATP synthesis and slip conditions. FEBS Letters, 445, 409-414.

Mulkidjanian, A.Y. 1999a. Photosystem II of green plants: On the role of retarded protonic relaxation in water oxidation, Biochim. Biophys. Acta, 1419, 1-6.

Haumann, M., A.Y. Mulkidjanian, W. Junge1999. Tyrosine-Z in oxygen-evolving photosystem II: A hydrogen-bonded tyrosinateBiochemistry, 38, 1258-1267.

Gopta, O.A., Feniouk, B.A., Junge, W., Mulkidjanian, A.Y., 1998. The cytochrome bc1 complex of Rhodobacter capsulatus: Ubiquinol oxidation in a dimeric Q-cycle? FEBS Letters, 431, 291-296.

Mulkidjanian, A.Y., A. Hochkoeppler, D. Zannoni, L.A. Drachev, B.A. Melandri and G. Venturoli. 1998. Photosynthetic electrogenic events in native membranes of Chloroflexus aurantiacusFlash-induced charge displacements in the acceptor side of the photosynthetic reaction centerPhotosynth. Res. 56, 75-82.

Gopta, O.A., D.A. Cherepanov, A.Y. Semenov, A.Y. Mulkidjanian and D.A. Bloch. 1998. Effect of temperature and surface potential on the electrogenic proton uptake in the QB site of the Rhodobacter sphaeroides reaction center: QAQB ® QAQBH2 transition, Photosynth. Res. 55, 309-316.

Ahlbrink, R., M. Haumann, M., D.A. Cherepanov, O. Bögershausen, A.Y. Mulkidjanian., and W. Junge. 1998. The function of tyrosine-Z in photosystem II of green plants: Effects of the pH, the temperature, and the H/D-isotopic ratio on the rates and extents of electron transfer, proton release and local electrochromism in the inactive and oxygen-evolving preparations, Biochemistry, 37, 1131-1142.

Gopta O.A., D.A. Bloch, D.A. Cherepanov and A.Y. Mulkidjanian. 1997. The temperature dependence of the electrogenic reaction in the QB site of the Rhodobacter sphaeroides photosynthetic reaction center: the QA-QB ® QAQB- transition, FEBS Letters,412, 490-494.

Haumann, M., A.Y. Mulkidjanian, W. Junge1997. The electrogenicities of electron and proton transfer at the oxidizing side of photosystem II, Biochemistry, 36, 9304-9315.

Mulkidjanian, A.Y. and W. Junge. 1997. On the origin of photosynthesis as inferred from sequence analysisA primordial UV-protector as common ancestor of reaction centers and antenna proteins. Photosyn. Res., 51, 27-42

Mulkidjanian, A.Y., D.A. Cherepanov, M. Haumann and W. Junge. 1996. Photosystem II of green plants: Topology of core pigments and redox cofactors as inferred from difference electrochromic spectra. Biochemistry, 35:3093-3107.

Mulkidjanian, A. and W. Junge. 1996. New photosynthesis or old?. Nature, v. 379, p.304-305

Mulkidjanian, A. , G. Venturoli, A. Hoechkoepler, D. Zannoni, B. A. Melandri, and L. Drachev. 1994. Photosynthetic electrogenic events in native membranes of Chloroflexus aurantiacus: Flash-induced charge displacements within the reaction center-cytochrome c554 complexPhotosynth. Res. 41:135-143.

Mulkidjanian, A. Y. and W. Junge. 1994. Calibration and time resolution of lumenal pH-transients in chromatophores of Rhodobacter capsulatus following a single turnover flash of light: proton release by the cytochrome-bc1 complex is strongly electrogenicFEBS Letters. 353:189-193.

Shinkarev, V. P., L. A. Drachev, M. D. Mamedov, A. J. Mulkidjanian, A. Y. Semenov, and M. I. Verkhovsky. 1993. Effect of pH and surface potential on the rate of electric potential generation due to proton uptake by secondary quinone acceptor of reaction centers in Rhodobacter sphaeroides chromatophoresBiochim. Biophys. Acta 1144:285-294.

Semenov, A. Y., D. A. Bloch, A. R. Crofts, L. A. Drachev, R. B. Gennis, A. Y. Mulkidjanian, C. -H. Yun, V. P. Shinkarev, M. I. Verkhovsky, B. S. Kaurov, and V. P. Skulachev. 1992. Electrogenic events in chromatophores from Rhodobacter sphaeroides lacking high-potential cytochrome b of the cytochrome-bc1 complex.Biochim. Biophys. Acta 1101:166-167.

Mulkidjanian, A. Y., M. D. Mamedov, and L. A. Drachev. 1991. Slow electrogenic events in the cytochrome-bc1 complex of Rhodobacter sphaeroidesThe electron transfer between cytochrome b hemes can be non-electrogenicFEBS Letters 284:227-231.

Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, and M. I. Verkhovsky. 1990. Electrogenesis associated with proton transfer in the reaction center protein of purple bacteria Rhodobacter sphaeroidesFEBS Letters 259:324-326.

Mulkidjanian, A. Y., M. D. Mamedov, A. Y. Semenov, V. P. Shinkarev, M. I. Verkhovsky, and L. A. Drachev. 1990. Partial reversion of electrogenic reaction in ubiquinol:cytochrome c2 reductase of Rhodobacter sphaeroides under the neutral and alkaline conditions. FEBS Letters 277:127-130.

Verkhovskii, M. I., L. A. Drachev, M. D. Mamedov, A. Y. Mulkidjanyan, A. Y. Semenov, and V. P. Shinkarev. 1990. The electrogenic step associated with the secondary acceptor semiquinone formation in the reaction centers of purple bacteria. Biokhimiya 55:387-394.

Verkhovsky, M. I., N. P. Grishanova, M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, and V. P. Shinkarev. 1990. The mechanism of interaction between the photosynthetic reaction center and cytochrome-bc1 complex in chromatophores from the non-sulphur purple bacterium Rhodobacter sphaeroidesBiokhimiya55:1202-1209.

Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, M. I. Verkhovsky, B. S. Kaurov, and V. P. Skulachev. 1989. Flash-induced electrogenic events in the photosynthetic reaction center and cytochrome-bc1 complex of Rhodobacter sphaeroides chromatophoresBiochim. Biophys. Acta973:189-197.

Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, and M. I. Verkhovsky. 1989. Transfer of ubiquinol from the reaction center to the cytochrome-bc1 complex in Rhodobacter sphaeroides chromatophoresFEBS Letters 245:43-46.

Verkhovsky, M. I., L. A. Drachev, M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, and V. P. Shinkarev. 1989. Electrogenic protonation of the reaction center ubiquinone in chromatophores of non-sulphur purple bacteria. Dokl. Akad. Nauk SSSR 304:209-212.

Drachev, L. A., M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, V. P. Shinkarev, and M. I. Verkhovsky1988. Phase II of carotenoid bandshift is mainly due to the electrogenic protonation of the secondary quinone acceptor. FEBS Letters 233:315-318.

Verkhovsky, M. I., L. A. Drachev, M. D. Mamedov, A. Y. Mulkidjanian, A. Y. Semenov, and V. P. Shinkarev. 1988. Generation of transmembrane electric potential difference in the cytochrome-bc1 complex of purple bacteria. Biol. Membrany. 5:51-64.

Mulkidjanian, A. Y., V. P. Shinkarev, M. I. Verkhovsky, and B. S. Kaurov. 1986. A study of kinetic properties of the stable semiquinone of the reaction center secondary acceptor in chromatophores of non-sulfur purple bacteria. Biochim. Biophys. Acta 849:150-161.

Mulkidjanian, A. Y., M. I. Verkhovsky, V. P. Shinkarev, V. D. Sled', N. P. Grishanova, and B. S. Kaurov. 1985. Study of photosynthetic electron transfer reactions by redox probes: Electron transport in non-sulphur purple bacteria. Biokhimiya 50:1786-1796.

Shinkarev, V. P., A. Y. Mulkidjanian, M. I. Verkhovsky, and B. S. Kaurov. 1985. Investigation of the kinetic and thermodynamic properties of the photosynthetic reaction center secondary acceptor in chromatophore membrane of nonsulphur purple bacteria. Biol. Membrany 2:725-737.

Sled', V. D., A. Y. Mulkidjanian, V. P. Shinkarev, M. I. Verkhovsky, B. S. Kaurov, and A. B. Rubin. 1984. Direct spectrophotometric determination of the midpoint potential of primary and secondary quinone acceptors of photosynthetic reaction centerBiokhimiya 49:204-208.

Verkhovsky, M. I., B. S. Kaurov, A. Y. Mulkidjanian, V. D. Sled', D. A. Cherepanov, and V. P. Shinkarev. 1984. Study of photosynthetic electron transfer reactions by redox probes: Principles of dynamic redox potentiometryBiokhimiya 49:394-402.

Sled', V. D., M. I. Verkhovsky, V. P. Shinkarev, A. Y. Mulkidjanian, N. P. Grishanova, and B. S. Kaurov. 1983. Interactions of redox-mediators with chromatophores of photosynthetic bacterium Rhodospirillum rubrumMolek. Biologiya 17:33-41.

 

 

Letzte Änderung: 13.12.2018 Katrin Jahns